Just a post that maybe will help someone else.  I was having some intermittent latency type issues on playback (glitchiness, pops) despite proper settings.  I recalled a thread that I believe Craig Anderton had started several months ago (searched for it but I cannot find it) regarding removing unneeded audio drivers.  I had 2 that were not tied to my interface (a RealTek driver that had installed with Windows, and a monitor-audio driver from an old monitor I used to use.)  I removed both of them.  Glitchiness gone immediately.  It may all be in my head, but I would swear the audio actually sounds cleaner.  I have not gone back and done A-B tests with/without, but that was my immediate perception.
 
At a minimum it improved the playback - must be some driver interference that was occurring.

Well of course it sounds better. No pops and crackles. DOH!

bapu
...No pops and crackles.
 

Poor Snap gets no respect. 
 

MorganT
It may all be in my head, but I would swear the audio actually sounds cleaner.  I have not gone back and done A-B tests with/without, but that was my immediate perception.

That's entirely possible. Think of what happens to the audio with MME if the latency is set just a bit too low...that's just one example of how a driver interacts with audio.

I laughed at your response Bapu, guess that part was obvious.  But apart from the absence of obvious noise, the music itself seemed cleaner.  This project has a lot of processing-hogging going on, I'm sure that's part of it.
 
Thanks for the prior input Craig.  I had assumed the "non-used" drivers wouldn't impact my sound, glad I'd seen that post before.  Guess I shoulda taken time then to remove/disable them.