If you are using a USB-connected audio interface, the default setting in Windows Power Management Advanced Options for something called USB Selective Suspend is 'Enabled', and this means that unless that setting is changed to Disabled, Windows will nuke USB-connected devices, such as midi controllers or an audio interface, and when this happens it can jazz things up.
Whenever I load up Windows on a new or reloaded computer, I always set the Power Management options to the High Performance plan, then further go into Advanced Settings and explicitly set USB-Selective Suspend to 'Disabled' and apply it or click OK back out.
Just a thought,
Bob Bone