Here's what UA finally replied with concerning my similar issue...
There are a few things I would recommend off the bat:
Boot OrderFirst, make sure you are always booting up the system in the following order (this is to make sure the Apollo makes a stable connection to the driver):
Turn on the Apollo first > Then turn on any additional peripherals > Turn on the computer last.
Uninstall / ReinstallIt would also be a good idea to perform an uninstall / reinstall of the UAD software in case the driver wasn't installed properly the first time:
When reinstalling, make sure to use the latest version of UAD software found at the link below:
Buffer SizeWhen using the Apollo via FireWire we generally recommend working at a buffer size of 512 or higher - you may be able to work at lower buffer sizes without issue depending on the specs of your computer however this is where you should start, and if you don't run into problems experiment with lower buffer sizes from there. A hallmark symptom of working at too low of a buffer size is audio drop outs and other audio artifacts that won't be present in the actual waveforms of your audio. Let me know if the problem persist working at 512 or higher using the two suggestions I mentioned above.