Hi,
I have an ISA 428 (four preamp unit) and purchased the digital board so I am not sure about the single channel ISA one. One advantage of the 428 digital board is that it can also be dropped into the 8 channel ISA 828 should you ever go in that direction and need the digital IO. The board also has Wordclock I/O.
Depending on the unit you have, it will allow you to have from 44.1 kHz to 176.4 kHz ADAT IO. The manual shows how to set jumpers to select the options and channel combinations.
I have only needed 44.1 kHz so I left my board as factory default.
Soundwise??? very clean and dependable in a nutshell.
I took a look at the Focusrite site and the board for the ISA One and it looks different than the one for the 428/828 so I assume that it is a single channel I/O with Wordclock.
Hope that helps!
h