Yeah . . . may be something going on with Melodyne (I have Editor version), I installed Sonar Platinum, smoooothly . . . when I opened an existing X3e project, right away there is a problem which automatically generates the cakewalk problem reporter, mentioning "melodyne" as being the issue, but when I try to submit the problem to cakewalk, the problem reporter locks up and hangs . . . sorry, couldn't wait more than 5 minutes, had to cancel it and restart Sonar.
So I try to open the same project again, and it works . . . opened other X3e projects with melodyne and they work . . . I'm hoping it just fixed itself ?
Tested, creating some new melodyne region fx, and melodyne editor seems to work fine on my system now, no crackles or pops . . . so, I can report that it is now working well for me.