jkleban
Happens to me often (large projects with lots of VSTi).... usually doing a SAVE fixes it for me for awhile. Don't ask me, it just does. (I think SAVE might clear out some memory, thus improving keyboard response time - QWERTY keyboard, not MIDI controller).
This has been happening to me randomly for years now.
Jim
The "lots of VSTi/memory" connection sounds interesting. If these are VSTi devices like Kontakt, then a lot of stuff could be loaded into RAM. There can be issues with memory not being released properly. I noticed that dke, whose avatar seems the most unhappy about this

, has a system with 8.1 and only 4GB of RAM which is kind of like putting your computer on a starvation diet. However, some of the sigs indicate people with 8 or 32GB having this problem, so it may be a combination of factors.
As mentioned, I don't have this problem but if saving fixes it, that would explain why. I save often just as a matter of "computer habit."
Whenever a project starts teetering, I'll close the project and re-open. That also seems to quell disturbances in the force.