All the channel strips on my tracks function fine. The EQ, compressor, tape sim etc.
 
However, the ones on the busses do not? No matter how much I crank EQ curves, or crank compression on the buss nothing happens?
This is a new install of Sonar X3 I am working with.

Do you mean the pro Channel on the buss?
 
Is the blue light on for the Pro Channel in the busses and the modules turn on?
 
 

Yes, the pro channel. The blue lights were on I know that, I tried another song and they appear to be working now, very strange!

Do you have the e patch installed?

Are your Busses set to Pre or Post? Sometimes, depending on effects that you may have in the bin, the Pro Channel may need to be set to post in order to hear it. For example: Drumagog. If I have Drumagog triggering a kick drum in the bin, but I use the Quad Curve EQ, I will not hear any change to the sound unless the Pro Channel is set to Post. This is because no matter what the source sound is or what is done to it, Drumagog sends the sound of the sample. But if my Pro Channel is set to Post, the EQ or anything else will indeed make a difference.