Short form...there's a reason why the "help" button exists on dialog boxes:
You click it when you need help!
I was working on developing a loop library and there were about 50 tracks with all the loops cut into phrases - lot of cuts. I started getting audio dropouts, so I increased the latency. Didn't solve the problem.
So I "Saved As" and deleted a bunch of tracks. Solved the problem for a couple minutes.
Then when the Audio Dropout warning box appeared for the umpteenth time, I noticed it had a "Help" button. Doh. I clicked it, and it suggested changing buffer settings and if that didn't work, to try the next thing. Well buffer settings weren't the answer, but then it mentioned audio fragmentation. My project was about as fragmented as could be without having a monkey hitting Split endlessly while moving the mouse around. Mr. Help (or maybe Ms. Help) said to save as a bundle file and re-open. I did. End of audio dropouts.
Now, how many times did I see that help button on the Audio Dropout box? I'd tell you, but I've embarrassed myself sufficiently already. You can lead a horse to water...