There DO appear to be drivers for this interface, per the Alesis web site, and the reference manual suggests trying both WDM and ASIO to see which driver mode works better for the given system.
From page 38 of the reference manual:
"For applications like Sonar that support both WDM and ASIO modes, you may want to experiment with each to see if either mode offers greater stability."
And the drivers can be downloaded from this site:
http://www.alesis.com/multimix8usb20 Click on the Docs and Downloads tab and you will see 32-bit and 64-bit drivers.
So, I look forward to getting some clarity on exactly what you did and how you have things set up. I will try to help you, if I can.
Bob Bone