Thanks for answering. The RME driver and firmware are up-to-date, and I'm running Sonar X3e. I notice Device Manager shows two entries for all Analog inputs except "Analog(1+2)" which only has one entry. I'm not sure if this is significant or not?

Sonar X2 shows analog outputs for Analog 1. This is actually for 1 and 2.
Sonar X3 does not show Analog output 1+2 (scrolling does not reveal missing outputs). Interestingly, it also shows the Realtek drivers, which RME recommends keeping around.