Well, you use the technology that's appropriate. I just did a bunch of bass loops with highly defined note attacks, so I repeated them in all keys to avoid pitch shift issues, and formatted them as REX files.
Be aware that pitch transposition is NOT a panacea and is difficult to do in real time. The further the transposition, the worse it sounds, especially with some instruments (like bass).
In those cases, here's another tip. After your arrangement is more or less done, make sure the clip isn't transposed and bounce it to itself. This converts it into a standard WAV file but that doesn't matter because the arrangement is done and you won't need to change its tempo any more. At this point, use the Transpose DSP function and you can change the pitch with much higher fidelity.
There are soooooooo many cool things you can do with Acidized clips, few people are aware of how fortunate we are that SONAR is only one of two programs that allows editing them.
If you're into any kind of EDM, especially electro, you
need to know
this groove clip technique.