The TASCAM US-2x2 is designed to take its power from the USB bus with Mac or Windows. However, if the computer doesn't provide sufficient power, then you need to use the optional AC adapter. The US-2x2
must use the AC adapter with iOS devices. The US-4x4 cannot be bus-powered, and requires using its included adapter for computers or iOs.
The main attributes of these interfaces are the mic preamp quality, the inclusion of 5-pin DIN connectors for MIDI in and MIDI out, and iOS compatibility (FWIW the Focusrite 2i2 is not spec'ed as working with iOS). Also, the zero-latency monitoring is stereo and crossfadable, not just switched, and TASCAM is now writing its own drivers in-house, which improves performance considerably compared to the previous generation whose drivers were supplied by a third party.
Disclaimer: TASCAM is part of Gibson Brands, as is Cakewalk. OTOH that means SONAR gets tested with the interface
Here's an article I wrote about latency that mentions the TASCAM interfaces.
Basics: Five Questions About Latency and Computer Recording