Thanks Craig. Ok, I get that, my OctaCapture is set at the default 6,which works fine 99% of the time when recording and playback and I don't have a problem with latency. It's just those times when making changes on the fly that things go wrong.
I remember reading on this forum somewhere that people change their buffers to optimise for recording and play back, but I'm not sure which to tackle, recording or playback, and in which direction. That is assuming that my problem stems from incorrect setting of these parameters.