I see some people here are very nervous about connecting to the internet due to the nasty stuff floating around, and others who aren't concerned at all. I'm going to describe what I do, and those who really know their stuff can tell me whether I'm doing anything wrong, if there are other steps I should be taking, etc. Ideally, this thread will become "The Complete Guide to How to Keep Your Music Computer Virus-Free Yet Still Use the Net When Needed."
1. My computer usually isn't connected. I connect only when I need something, and go to sites I trust like Cakewalk - I don't surf around.
2. I have Microsoft Security Essentials installed, so I figure that will catch anything excessively weird.
3. If I get any kind of notification, e.g. an update to Adobe Flash is available, I never click on it. Instead I go to the Adobe site and download the update from there.
4. I don't download anything unless it's something I've sought out to download, and only from company sites I trust (e.g., driver update from the TASCAM site, Windows update, new trial version plug-in from Universal Audio, etc.).
5. I have an older Mac running Snow Leopard that I use for general-purpose surfing and downloading. It's Intel, though, so probably not as safe as PPC (although it seems most browsers are incompatible with it anyway).