I'll start...
Comping and Melodyne were the huge ones for me. Next are QuadCurve EQ flyout, browser enhancements, and track colors; I don't use the tape emulator much but when I do, it's what the doctor ordered.
What I still need to check out are Strum Acoustic (ignored it initially because I play guitar, but the modeled sounds are quite cool), most of the Blue Tubes plug-ins (I have a lot of "old faithful" plug-ins and tend to favor the ProChannel anyway), Gobbler integration, and the BiFilter 2. Haven't done much with AD, but that's because I use mostly audio drum loops. The few times I played it with, I was impressed by the editability.
How about you?