I am a Noob, so I can play on TD-11 with AD2, even with audio output throw TD-11 (build-in Edirol). The last option is not really convenient, a bit too much latency. But throw "real" audio interface, it is ok for me.
When I had one of that "WT... is going on?" moments with MIDI latency, a friend was visiting me. He (also hobbyist) has not played with AD2 before, so I have switched on my system. He has tried with the conclusion "sorry man, but that is no playable...". I have tried myself - really "no go". I have turned on my DP and I could barely play it with TruePiano. I can play slow peaces with up to 30ms latency, but this time it was more. I took my MPK mini and surprise, the latency is as usual. I had no time for investigations, so I have turned the system off. Later, after turning it on again, everything was working properly again.
I am a kind of unlucky with music setups. Strange things happened exactly at times when that was more or less critical. Like continuously crashing with my notebook VS-20, after 2 days working fine and just several hours before I had to use the setup (that can be called lucky moment, that has forced me to buy RME which was a good move). Sonar has reverted to demo mode in the middle of video tutorial recording (which I do not do often). MIDI latency, when someone is visiting me. Etc.