I've used an acoustic amp and DI'd it into the main mixer in the past. The amp being there to provide some localised "just me" volume and better eq facilities for a piezo pickup than many mixers have. Worked fine.
Doing the same into a powered PA bin should work just as well so long as it can handle the level of signal the amp"s DI puts out, which is typically mic level if the DI out is on an XLR socket. The only problems I can forsee is if the PA speaker hasn't at least basic eq of its own and the eq for the amp sounds bad in the PA bin, and the potential for earth loops and hum.
Putting a cheap small mixer between the amp and PA bin might solve both those problems if they arise.