on some boards from ASUS...M.2 if selected, defeats or hampers TB...
So you have to do the homework and read the instructions and manuals properly...for I cannot read into it for you, nor will all here for you.
You have to go slow...read, understand what you are reading into...and proceed with caution...
If you are using M.2 with TB and firewire and usb..and and and...you are going to get odd noises!
So make up the mind...what port you wish to use...and look into how to employ it proper....first read the readme files...
and Manuals..for your system setup, irq's sharing...and make all redundant devices disabled....How you do that, is either by Bois setup proper, or through windows Device management.
Device manager /Power settings needs be tweaked, turn off all sleep mode, and monitor sleep, ..and no idol sleep on drives....and such setups can be set...to gain maximum performance of the system you have to tweak it for what you want it to do, with what you need for it to be done..and all parts sorted to get that.
Turn off system sounds.
Go into device manager systems, and make sure USB ports are set to not let windows turn this port off....((power management)) it is, but in a different part of the System page...device/systems/usb hubs...
And if you wish..another setting is to run in background mode, or program mode...but some say is dependent on what you need done.
HDMI audio might be tweaked to be turned off...it does help to do that....I found.
The cpu parking must be tweaked to off...using Cmd prompt.in admin form.
and set the cpu limit to 100% in that power tweaking session...might also help?
So you have home work to do on M.2...and your Mother board working with Firewire, and TB?.....and think about firewire or TB..but not both at the same time working...with m.2 Perhaps?
conflicts of irq's sought and told...what is in conflict must be showing up in the performance tab, or system info, or remote viewer for any issues....Right?
cheers