This past weekend, I was having some issues with latency (using the drivers for the newer 2i4).....tried changing the settings in the Focusrite panel, but still had very slight (noticeable) latency. Tried 48k as well as 44.1 with various different latency MS tweaks.
I then installed version 1 drivers which seemed a bit better (tweaked the Focusite Panel again), but not quite enough to win me over. However, I didn't have any dropouts or other issues....just latency
. I only had an instance of Amplitube 4 with an instance of TH3 running at the time.
Interestingly, I don't remember having any of these issues with Win 8.1, and all of this started happening fairly recently with Win 10 updates (although I had upgraded to Win 10 more than a year ago).
I do like my 2i4 as it's perfect for my needs (don't want to really shop for a new interface, unless I have no choice) and will possibly ask their support to walk me through to get a good stable setting....