Pragi
most this is the issues appear if the buffersize is not set to 1024 or bigger.
I never had the buffer size more then 256 and apart from "early bugs" and some other specific buggy operations I can not remember problems. Note that I have very slow computer and the only influence of the buffer size on possible troubles is under-runs and how particular DAW/audio driver able to deal with it.
Melodyne will get "heavy stress test" soon, once REAPER officially release ARA2 support.
Unlike in Sonar/CbB, the content is not locked there. ARA2 plug-in can be inserted as normal track FX. And adding new, editing, moving, etc. clips is still allowed. On the fly, even during playing/recording.
That already works almost fine, but it is still possible to produce a crash. Once related problems are solved, I guess Melodyne by itself will be rock solid.