One really strange issue I've seen with the pro channel (on my laptop running WASAPI), is a strange brick-wall limiter type effect when playing from bar 1. It's like a burst of volume that almost immediately settles down in a fraction of a second.
This happens when ProChannel is enabled regardless of whether any of the modules within the ProChannel are enabled or not.
Disabling the ProChannel makes it go away.
My usual workaround of leaving an empty bar at the beginning of the project fixes this, but it's strange that just having the ProChannel enabled causes this behaviour.