All of my sampled instruments by different makes and makers, both professional, are out of tune by 4.33 on multiple tuners (micro cents???). Is this a problem that can be fixed in Sonar or even an explanation or should I just not worry about it?

I am assuming you are checking the tuning of Cakewalk output, although you do not say how or where the signal is tested. If it is a digital tuning meter checking some point in the digital signal path that is one thing. If it is in air, from a transducer like a speaker then that opens a whole other can of worms. If you are not using Cakewalk, or if the symptom is present on multiple sample playing applications or vst hosts that is another issue. If the issue occurs when you are playing a note hand written into piano roll that is a different issue than if you are using and outboard MIDI controller (keyboard) to write the events.
 
The first thing I would think in this case is that there is a stuck pitch bend event somewhere. But with this tiny and consistent variance, the clock (computer, audio interface ?) that you are using would also potentially be an issue. I am afraid you will need to provide a lot more tedious information in order to get a decent answer.

Hey Ricky - If you have Melodyne (Sonar X3 thru Platinum, I believe), you can fix out of tune samples with that
                 Explanation: they were recorded out of tune
                 Worry about it? - That's up to you and your ears    😎
Good luck!  

99% of the time this topic comes up it was caused by a controller that is transmitting , try disconnecting your controller. 
 
Also, as said look in the event viewer,  if your controller has been transmitting a mod wheel cc event then every project since it went south might be off. 
 
So== Open a new project , insert a synth and see if that is out of tune when you play it using the GUI or PVR left hand piano keys. 

Such a consistent behavior among all your software & tuning meters could point to the sound card itself. Yours is what?
 
4.33 cents high is like 440 Hz tuned to just above 441. Just over 0.23 % off. That's more than a typical DAC tolerance, but maybe not out of the question for some sound cards.

Sample rate mismatch, perhaps?  Also, what happens if you load up a stand-alone synth and see if it plays notes in tune when some known audio track from a CD is played with Windows Media Player or Groove - like China Grove in E, for instance?
 
Bob Bone
 

It is worth thinking about a sample rate mismatch, but the math does not exactly work out for that. Assuming an equal tempered scale, +4.33 cents error would equal a frequency ratio of variant pitch/ true pitch = 1.00250. The twelfth root of two raised to the 0.0433 power.  The ratio of 48Ksps/44.1Ksps = 1.0884 (inverse 0.91875) consistent with a pitch variance of + or - 146.7 cents.
 
It is very unlikely that sampled instrument content from multiple different suppliers would have been out of tune to the same degree. It is more likely that the tuner is in error, but again if different tuners are getting the same result to this level of precision that would be very surprising. I take it that he is reading cents and not semi-tones on his tuner.
 
If the OP ever returns, he may fill us in on how and where in the signal chain he is measuring the intonation, whether the samples are sharp or flat according to his tuner,  and whether the same instruments loaded into a different DAW are also out of tune to the same degree.

What audio card? I know my rme card has the ability to shift the frequency by + - 5%.
If this were accidentally changed it could cause something like this.