I routinely left my old MOTU on for literally weeks at a time, sometimes months. It lasted for years. Right up until the day it died at the ripe old age of 7.
Fearing I'd shortened its life by turning it off so infrequently, I now make a point of powering down its replacement when I shut down at night. Probably for nothing, though. In reality, turning it on probably stresses it more than leaving it on (ever notice how light bulbs fail just as you turn them on?).
Assuming it wasn't crazy hot that week, any piece of solid-state electronic gear that can't handle being on for a week is garbage, and Focusrite stuff ain't garbage.