Thanks Grem, but I got it now - it was to reinstall the Yamaha USB drivers (for my UR-22).
Anything using sound was affected - Cubase, Cakewalk, Kontakt, Amplitube, EWPlay, etc.
Wavelab opened ok, but when I went to preferences, I then got the Windows installer issue.
Windows, as usual thinks it knows better about the configuration.
I have the XLN reauthorisation problem, but that's expected and a fairly easy fix.
Anyway - all fixed now
Cheers to all