You'll find that most current generation motherboards do not have the Thunderbolt-3 controller onboard.
ASRock, Gigabyte, and Asus all have moved to an optional AIC (add-in-controller).
Make sure the motherboard specifically has a Thunderbolt-3 header.
Make sure the BIOS specifically supports the Thunderbolt-3 AIC.
Make sure you can source the specific Thunderbolt-3 AIC. There are times when stock is hard to find.
Depending on the Thunderbolt audio interface (most are still Thunderbolt-2), you'll need a Thunderbolt-3 to Thunderbolt-2 adapter. Several audio interface companies (including Presonus) recommend the StarTech adapter. The Apple adapter is about $20 less, is easy to source, and has worked in every scenario we've tested (lots of different laptop/desktop configurations). The Apple adapter works just fine with the Presonus Quantum (I'm running that combination here).