Hum? I'm just wondering... I don't have this unit but sometimes things seem relevant.
Do you have your Clock set to internal?
If you have some type of Software like an internal mixer that goes with your interface check for clipping internally.
Are you using a power conditioner to power your gear?
Within the Windows/ control panel/ Device manager make sure that you have no other audio devices installed or just set to off.
Your "audio ins and outs" should only have your Audio device listed. Also look under Sound, video and game controller.
No other audio devices should be there except your device. Delete all others, otherwise windows will decide what to do for you. If your audio interface boots slow windows could be setting up crap drivers in the background.
I wound uninstall all audio drivers then reboot the computer. go to device manager and make sure there are not Audio devices installed. The reinstall your device and reboot. after that go back to the device manager and make sure all other devices are gone.
Hope something here helps! :)
peace!