I use a Kingston Orbit wired trackball mouse. It has just two large buttons. Left click and right click.
It gets me around dual extended 27 inch monitors very smoothly and precisely.
It's a trade off though. What it lacks in features, it makes up for in effortless, precise control.
Ive gone through a few mice searching for good SONAR control and found I like the combination of trackball, keyboard and MIDI controller best.
Good luck!