Hi,
I have a 56 and it has been very reliable. When I was researching fire wire interfaces, I learned that the Texas Instruments chip set was the most reliable (might want to check that). There is a switch to set the L56 back to factory defaults from Mix Control, but since you can't see the unit, that will not help you - maybe Focusrite has a "back door" method for that and not sure if the stand alone mode will cause problems.
Some thoughts:
You might want to try to swap out the fire wire cable. I had a few times when the 56 did not connect and I found that restarting everything usually did the trick. Shut down the 56 and your PC then restart the 56, then the PC. If they talk, the FW active LED will illuminate green on the front of the 56 (right side - above the headphone pot). You also probably know that you should not pull the fire wire cable out of either the PC or 56 while they are on (shutdown everything first). Sorry if I am repeating something you already tired :-)
Looks like you already checked with Focusrite, but there is also a troubleshooting guide for the 56 at:
https://support.focusrite...-Troubleshooting-Guide