DrLumen
I move the mouse in large circles until I see the pointer fly by in one of the monitors.

Yes :)

..except those time when I shut off 2 monitors when not operating DAW.

Here is an Autohotkey command to position the cursor on the main monitor.
 
DllCall("SetCursorPos", int, 100, int, 400)
 
If you are not familiar with Autohotkey and want a program created for a specific hot key give me the keystrokes and I will compile a script for you

scook
Here is an Autohotkey command to position the cursor on the main monitor.
 
DllCall("SetCursorPos", int, 100, int, 400)
 
If you are not familiar with Autohotkey and want a program created for a specific hot key give me the keystrokes and I will compile a script for you

Thanks, scook. I'll be reading up more on Autohotkey.

Meanwhile, I'm running this power shell script (copied else where) which seems to work - just not instantly.

The hotkey runs a Windows shortcut file (must be in the desktop) with the following properties :- 

target :

%systemroot%\system32\windowspowershell\v1.0\powershell.exe -ExecutionPolicy RemoteSigned -File "C:\My Scripts\CenterMouse.ps1"

start in :
%windir%\system32\windowspowershell\v1.0

short cut key : Ctrl + Alt + M (can be any letter)

---- 
[System.Reflection.Assembly]::LoadWithPartialName("System.Drawing") | out-null
[System.Reflection.Assembly]::LoadWithPartialName("System.Windows.Forms") | out-null
$bounds = [System.Windows.Forms.Screen]::PrimaryScreen.Bounds
$center = $bounds.Location
$center.X += $bounds.Width / 2
$center.Y += $bounds.Height / 2
[System.Windows.Forms.Cursor]::Position = $center
---