The Samsung Magician that comes with the Evo drives will give you the best performance options.
I wish other SSDs came similar tool sets (maybe some do, the Mushkin I picked up for my other system didn't)
As for tweaks you have to decide what you want more performance vs reliability - SM does pretty good job at explaining the options and giving control over them (or if not control explaining what to tweak - been a while since I last played with it so don't remember 100%).
I've opted for performance and I haven't seen any app or setting tweak that appears to do more than what S.M. does or recommends.
SM has Rapid Mode which seemed pretty impressive. It can give you a nice performance boost but it can only accelerate one drive in the system.
You say your getting audio glitching but you don't say how you have the 3 drives connected and that may be a factor.
Or it could totally be something else.
I have an Evo 1TB SSD as my C: drive on my laptop. If I don't turn off my WIFI I get glitching and audio engine crashes.
Hope this helps.
...Steven