Yes, I tried uninstalling the drivers using Device Manager and re-installing the "latest" Firepod drivers which are quite old (PreSonus stopped updating them in 2010).
I'm not sure if uninstalling actually removes the files from the Windows system or if I have to do manual steps. Likewise, I don't know if I should try to find all references to those drivers in the Windows Registry and manually delete keys. If I have to go that route, I'll definitely backup the Registry first.
If the driver files are indeed removed with the uninstall then I don't think they were corrupted. There was probably some dependent DLL that was updated (or removed) that is now preventing the driver from starting.