Leadfoot

BlixYZ
Audient would suit your needs.

+1000
I have the Audient iD22, and it sounds beautiful. Awesome mic preamps that respond well to being driven hard. It also doubles as a great monitor controller. Runs about $600.

 
Or maybe the Audient iD14, which is essentially a cut-down version of the iD22, would be sufficient. It has the same pre-amps but only has one pair of main outs, no send & return, plus a few other things absent. But it seems to fit the OP's desription very closely and it's a lot cheaper too.

OK. I get that the Audient hardware and preamps, etc. are great, but how do the drivers compare to MOTU and RME?  The reason I'm asking is if what if you don't plan to plug in any instruments, but want to use a ton of soft synths without any latency (well more than 5ms, more or less).

The drivers have been rock solid for me.

Thanks for the continued comments guys. And yes, since 90% of my music is 100% soft synth (every once in a while I use my guitar or have vocals), the most stable Windows drivers possible is probably #1 on my list.
 
To be honest I never ever touch my interface. I just plug it into the computer, plug my monitors into it. Adjust the volume knob. Otherwise it just sits there haha.
 
Seems like so far the ones I'm going to be doing the most thinking about are:
 
- Audient iD14
- RME Babyface
- MOTU AudioExpress
 
I'm gonna do a ton of homework on them and also ask PC Audio Labs who built my PC if they have any recommendation. Obviously the Audient is much less expensive then the next two, but the the RME & MOTU have such pedigree with their drivers... then again I heard nothing but positive things about the Focusrite until after I got it so who knows haha.
 
Thanks

I used to use a Saffire Pro 24 and had no issues... I upgraded this year to the MOTU Ultralite mk4.  Prob a bit more money and features than the AudioExpress but it is a newer technology.  I wasn't sure if I needed the extra features of the Ultralite AVB, and the RME was preferred but a bit too much cost.  So far so good.

Take a look at the TASCAM UH-7000.  Topnotch conversion, better pres than any other interface I've heard - they are worth the price of admission by themselves even if you are only recording audio every once in a while.  Not the best latency, but I don't have a problem and I mostly use soft synths.  If it is, you can digitally sync it to something faster and use those drivers - it is AES but can also do Spdif.  USB 2 so it should be compatible for a while.  And you can find them for $400 or so new. 
 
Another option is Lynx.  They have a new PCI card 2 x 2 unit out, and a rack mount  8 or 16 track unit over USB, dante (I think), AES etc.  The old units should be relatively cheap now - the new ones run from $1000 on up.  If I had the funds that is the way I'd go.

AT
Take a look at the TASCAM UH-7000.  Topnotch conversion, better pres than any other interface I've heard - they are worth the price of admission by themselves even if you are only recording audio every once in a while.  Not the best latency, but I don't have a problem and I mostly use soft synths.  If it is, you can digitally sync it to something faster and use those drivers - it is AES but can also do Spdif.  USB 2 so it should be compatible for a while.  And you can find them for $400 or so new. 

 
No offense AT, but this is exactly what I'm not looking for haha. Digital sync and AES and SPDIF and top notch conversion... I just want to plug my speakers into it haha. Also maybe ignorance is bliss but I would be shocked if I noticed a difference in quality of the pres when I already think my Focusrite sounds as good as it can get since I do so little recording of real instruments/voices (when it works... grumble grumble haha)
 
Lynx on the other hand is another option I will take a look at. Thanks for the comment :-)

You will probably get at least 10 years out of an RME unit and really low latency.
Then again Focusrite use to have good driver support.
If you are using W10 remember it's not a mature OS like W7.

Polar,
 
you can use the digital in/outs if you need lower latency, not that you have to.  I get about 10 ms with the 7000 which isn't low but workable for most of my music.  That is a win 7 computer - it gets a little lower on my win 10 and I've not tweaked USB on either unit.  If I need lower latency or more tracks, I use it as a master in/out to a TASCam US USB 3 interface that does do low latency.  Both units together costs about $800.
 
As far as the pres, I would think you could hear a difference between the 7000s and a Focusrite pre.  I could with my older TC unit and even the US unit.  I use them right beside Warm and RND Portico pres - they are not better but different, cleaner with no transformers but still big sounding.  TASCAM brought the 7000 out as a premium unit at $700 about the same time Audient etc. started doing similar units.  Most of them are now below $500 simply because there aren't enough buyers at the higher prices.  It is a good time to be in the market.  I know the audient pres are the same as in their big boards.
 
@

I would suggest getting and internal PCI \ PCI-E soundcard with digital output \ input and a quality stand alone DAC | ADC