chuckebaby
You record a dry track and use FX during the mixing stages. In most cases now a day, most home studio users are recording dry DI/line level guitar in to an amp sim and then adding FX later.
Good to have dry guitars tracks to experiment with some FX and amp sims after recording, but when creating/improvising solo's, hooks, even some rhythms, you really need the FX applied, amp sound and volume levels while playing, as it affects the way you play and inspires some of the sounds that you create which you may not create playing/listening dry, and many sounds you can't easily reproduce later by simply adding FX, (say like expressions and feedback), I guess splitting the signal and recording both the dry and wet on separate tracks would be ideal. I do usually record direct, (not mic'd), from amp using MESA CabClone, and rarely monitor the electric guitar Im recording through the DAW/Amp Sims/FX, and studio monitors or headphones, although have done so to experiment with some of the FX chain presets sounds, not saying its a bad thing if you're getting sound you want without latency issues. If I do want to record/monitor dry electric plugged directly into audio interface or often with acoustic guitar I would be monitoring direct signal from audio interface mixer not going through DAW.
Otherwise not sure if its feasible/safe to route guitar through AI/DAW/FX and out into a guitar amp to make use of DAW FX through a guitar amp? (I guess you'd need to convert line level back down to a mic/instrument level or the amp would need to have a line input available?).
Cheers