tlw
As a general rule though, single coils tend to have less mids, a bit less bass and more top, and the strongest frequencies/point of maximum Q tends to be both narrower and higher than humbuckers. Guitars put out very complex waveforms though, and getting something like convincing Strat "quack" and frequency cancellation when two pickups are on may be difficult. The easiest sort of eq fix might be to make a bridge 'bucker sounding more like a Tele bridge or a P90.
+1 to this.
DiMarzio's site is another resource to check (Humbuckers vs Strat-style on the left) - they use a scale of 1-10 for each frequency band so is a bit easier to visually compare. As tlw stated, in general, single coils are more bright (sometimes "brittle") with less "mud" on the bottom end than a humbucker. The mids can be comparable, depending on the pickups chosen.
FWIW, I have a DiMarzio D Activator set in my guitar (both are wired to cut-coil but rarely used in this manner). The
neck is incredibly bright, but not brittle (very similar to most Strat's specs), while the
bridge is pretty flat-lined. I bought them because they boasted "the most power output without active electronics" when I purchased them, and they are quite powerful and incredibly clean. Just in case you get into projects in the future, that set (even not wired for cut-coil) is very versatile "as is."