OK, tried to quickly correct last summary:
 
No Issue Reported:
Intel HD4000
Intel HD3000
 
Issue Reported With:
Radeon HD5450 (1 report with issue, one report without)
Intel HD4600
Intel HD530
Nvidia GTX 1060
Nvidia GTX 960 (1 report with issue, one report without)
Nvidia Geforce GTX 970
Nvidia GeForce GTX 750 Ti
1024MB ATI AMD Radeon HD 5570 (MSI)
 
Reinstall of .05 Update: No reports of that fixing issue
Rollback to .04 Update: all reports state that fixes issue
 

dcmg
OK, tired to quickly correct last summary:
 
No Issue Reported:
Intel HD4000
Intel HD3000

Issue Reported With:
Radeon HD5450 (1 report with issue, one report without)
Intel HD4600
Intel HD530
Nvidia GTX 1060
Nvidia GTX 960 (1 report with issue, one report without)
Nvidia Geforce GTX 970
1024MB ATI AMD Radeon HD 5570 (MSI)
 
Reinstall of .05 Update: No reports of that fixing issue
Rollback to .04 Update: all reports state that fixes issue

I have a GTX 970, GTX 860m, GT 430, and Intel HD4600, but haven't been able to replicate.
 
Personally, I'm not convinced it's an adapter issue just yet, though it's good to keep track.
 
Edit/Update: Just found out QA/Dev may have squashed this for 06.2017, we're still investigating DPI changes and stuff though.

Thanks Seth.
Graphics and mouse use seem pretty random. Thanks for keeping on it.

 It may be a particular driver version associated with each of those graphic cards.  I have 2 computers on which I run SPLAT. Never at the same time, of course.  I don't have this issue with either one.    
AMD Radeon R9 M200x    Driver 22.19.157.3            dated 04/2017
ATI   Radeon HD 4600      Driver 8.970.100.9001       dated 1/2015
 
I will try updating the ATI driver and see if the issue appears!

Is this something that could be originating in the Mouse Properties in Control Panel?  Does it still happen if you choose a scheme like extra large?

Thedoccal
Is this something that could be originating in the Mouse Properties in Control Panel?  Does it still happen if you choose a scheme like extra large?

 
Good question. Hard issue to trouble shoot.
In my case ( and likely others) I have client work to do and can't troubleshoot, so most of us roll back to .04 and then can't keep investigating.
 

Thedoccal
Is this something that could be originating in the Mouse Properties in Control Panel?  Does it still happen if you choose a scheme like extra large?

I am using the Extra Large Mouse pointer scheme on both my computers where I don't have an issue.
 

I had to roll back as well, unusable,  I have a gtx550ti.   When I looked in speccy for the 1st time "The system cannot find the file specified" (only on the graphics section) I have a roccat mouse.  

I am running a 
GeForce GTX 750 Ti
I also have a Wacom Intuos pen & touch medium.
I have touch turned off. 
 
 
Had to rollback the update to get anything done in Sonar.

frankjcc "The system cannot find the file specified"

this is sometimes a mis-reported/labelled permissions errror msg