Along with checking in device manager for USB hubs being turned off in the ‘power management’ tab, make sure the Win10 computer isn’t being started under ‘fast boot’ and using a hibernation file. Someone may have already said this. But the ‘fast boot’ option totally screwed with USB ports and other drivers. And I need to check it with major win10 update as the updates have occasionally re-enabled each one.

I do have a MOTU MTP AV midi timepiece. It works just fine with my Win10 computer. Looking in device manager, the driver is from motu and date is 4/30/2013. Driver version says 4.0.5.7843

bwbalint
Along with checking in device manager for USB hubs being turned off in the ‘power management’ tab, make sure the Win10 computer isn’t being started under ‘fast boot’ and using a hibernation file. Someone may have already said this. But the ‘fast boot’ option totally screwed with USB ports and other drivers. And I need to check it with major win10 update as the updates have occasionally re-enabled each one.

I do have a MOTU MTP AV midi timepiece. It works just fine with my Win10 computer. Looking in device manager, the driver is from motu and date is 4/30/2013. Driver version says 4.0.5.7843

Thanks for concurring that these old flagship interfaces still do work with Win10.  I too am thinking that it may very well have something to do with an update....and I am convinced that it is just a setting somewhere that has gotten changed somehow.  I appreciate all of the comments and suggestions from everyone, and I am I am in no way discounting what you are saying... but I just can't understand how a computer can get "too fast" for a piece of equipment to not work anymore when it comes to MIDI.  If it was a processor hog piece of equipment that was bogging down a processor I could understand that.  But as far as updating to a new interface....MOTU still sells 8 port MIDI interfaces...and they use the same driver as far as I can see on the website...and supposedly work fine (as proof since yours is still working) :) .
 
I had thought about just buying a new Yamaha digital piano with a USB port to use as a controller as well...but I'm just the kind of guy who doesn't like something to whip me...and by golly I'm gonna put up a heck of a fight before I give up...lol.  Thanks again guys and gals.  This forum has always been such a great source of info and help.  Again...I appreciate all the info.

Update:  I have two PCs in my studio...one for audio / video production, and another for desktop publishing, internet, etc.  Both have Win 10 Pro installed.  I went ahead and installed CbB on my other computer...and everything MIDI worked like a charm.  SO...it has to be my screamin' eagle PC USB ports causing the problem.  At least I've narrowed it down to the culprit.  :) .

Whip its butt, Ted! I'm the same way, I get entertainment value out of trying to get old stuff to work, but I never assume anyone else is like that. I'll spend days trying to get an old M-Audio interface to work when I can get a brand new Tascam that will drop right in for $50.
 
I wasn't thinking that the MIDI part of it was too slow, rather the part where the USB talks to the interface. Anyway you now have concurrence that it will work under Windows 10 on a modern system! Maybe there's a setting in your system BIOS for your USB ports that will help?
 
Also, y'might get on over to the CbB forum, as this one is crumbling around us as we speak....

Thanks a bunch Euthymia...!  I see you have felt my pain too...lol.  I did go into the BIOS and made sure that FAST BOOT was turned off in the BIOS as well as in Control Panel.  I have checked about all of the settings in the BIOS but will go back in and check deeper tomorrow with all of the peripheral settings.  It has actually turned into a mission...although it could end up being Mission Impossible.... :) .

I have had a pcie usb2 card fail. Started to act squirmy, then nothing worked that was plugged into it. New card and it all works again. Easy on a desktop. A bit more difficult on a laptop. Good luck!

bwbalint
I have had a pcie usb2 card fail. Started to act squirmy, then nothing worked that was plugged into it. New card and it all works again. Easy on a desktop. A bit more difficult on a laptop. Good luck!

Tried different USB ports...including front mounted ports.  But thanks for the tip.