Back in the older times, I remember a lot of tweaks were available.
Now a days, I just run it till something comes up and I have been lucky enough where... well nothing has come up.
With a good sound card, a good PC build- this includes good ram, good HD, EXC.
You should be good to go right out of the box. none of that core parking crap or anything.
As Dave said, Make music.
You can set your midi buffer to 500 and if you need audio set up asst.
https://www.cakewalk.com/Support/Knowledge-Base/Audio-Hardware-Setup-Guide