hey Gswitz, can't tell you the solution excactly from simular thing had while ago with my Sonar and RME.
must have been something with having another programm open that uses the audio drivers combined with recent changes to sample rates or bit depths iirc.
Would just restart the computer, leave off the RME mixer screen and start a new Sonar project and should be ok.
Nothing to worry about imo, just a software conflict with multiple bit depths/sample rates/programms etc if I"m correct.