Rimshot
My question is how much quality could I be missing by not using a tube preamp going into the DAW?
Since I can apply a tube VST effect to it anyway, how much difference can the end sound be?
This especially releavant to mixing a song. By the time all is said and done, does applying tube efx to a vocal after the fact make up for not using a tube preamp from the get go?
The answer, I think, is "it depends".
Firstly, you have to define "warmth" and why that might, or might not, be a good thing. You also have to define "quality". So in the end it's down to what your ears tell you.
There will be a difference between using a valve pre-amp routed into the (solid state) interface and just using solid state and adding plugins afterwards. For a start, there's how well the plugin actually emulates not just a valve, but the entire circuit - transformers, power supply circuit etc. - that surrounds it. Even if the emulation is perfect you're still going valve->solid state in one configuration and solid state->"valve" in the other. Which means the result won't be the same because the first configuration is an ss circuit modifying what comes out of the valve pre and the other is a "valve" modifying what comes out of the ss preamp and interface.
Having said that, in my opinion emulation of valve circuits is a very mixed thing. Some are good, some are poor, others don't sound a bit like the "real thing" but still make a usable, but different, result. I'm happy to use some emulations of hardware, less so others - in particular I find amp/guitar fx emulators to on the whole be very "fake", but millions of people use them so what do I know.
The thing about valves is that in a lot of circuits, guitar amps aside, they weren't intended to produce harmonic distortion, they were the best attempt at the time to design and build as quiet and accurate a circuit as possible, with the unavoidable side effects of the technology hopefully being either minimised ot tweaked tomsound good anyway. That to me is the kind of circuit most successfully emulated. What emulations can't do of course is let you swap a JJ 12AX7 for an old Philips 7025 then try a modern Tesla and so on. And different manufacturers valves can and do sound different even though they're electronically compatible and supposedly the same specification.
For pre-amps, compressors and other gear not being pushed into much overdrive many plugins are actually pretty good I think. Personally I have no aching desire for a high-end valve mic pre-amp, but I'm very fussy about what goes into my guitar amps.
And as batsbrew says, most recordings from the late 60s onwards were mostly made using solid state consoles or solid state stand-alone hardware. It was transistors that made the big multi-channel desk viable. Valves may be better under some circumstances than solid state at creating a musical sound in the first place, but for consistency, accurate sound capture and minimal unwanted effects at the mixing/mastering stage transistors have a lot going for them. And solid state circuits also have their own individual characteristics.....