Hello, I've had this focusrite 2i4 2nd gen audio interface for around a month now. Inside sonar professional, I have had nothing but issues. I have a lot of latency and skipping as well. I have tried lower the latency and raising it, that doesn't do anything. I've searched forms, did what they suggested and still no solution. I like to play a plug-in while a drum track is looped and I can't due to these problems. I'm frustrated and not sure what to do. Any help is greatly appreciated, thanks.

Background processes like wi-fi can cause problems.  To see what might be running in the bg, go to Task manager-startup tab and disable any unneeded utilities that are enabled for bootup.
 
Also, try connecting your interface to a different USB 2 port. (They are not created equal.  I'd avoid USB 3 ports altogether for audio interfaces, as they're not as backwards-compatible as they claim).

What are your system specs and what are your driver settings?  Many people use that interface without issue, so I am sure we can get the problem sorted out.

YellaVeL.rk
Hello, I've had this focusrite 2i4 2nd gen audio interface for around a month now. Inside sonar professional, I have had nothing but issues. I have a lot of latency and skipping as well. I have tried lower the latency and raising it, that doesn't do anything. I've searched forms, did what they suggested and still no solution. I like to play a plug-in while a drum track is looped and I can't due to these problems. I'm frustrated and not sure what to do. Any help is greatly appreciated, thanks.

I've had similar symptoms with the 1st gen Scarlett. It is advised to add your DAW folders to the Windows Defender exceptions list, even if you have the anti-virus disabled.
Besides that, here is an excerpt from power config setup instruction I've found somewhere:
 
Disable USB Power Management
This helps prevent power issues with devices that are powered by USB.
1. Open Control Panel, then click on Device Manager.
2. Open the Universal Serial Bus Controllers menu.
3. Right click on the USB Root Hub in the menu and choose Properties
4. Go to the Power Management tab and un-check the the box to ‘allow the computer to turn off…’
5. Repeat this for each of the USB Root Hub’s that show up in device manager
 
Adjust Power Options
1. Click on the Windows Start button and choose Control Panel
2. In Control Panel choose Power Options
3. In Power Options, choose High Performance
4. To the right, click Change Plan Settings
5. Choose “Change Advanced Power Settings”
6. At the top of the Advanced Settings window, change to “High Performance” in the menu.  Open USB settings> USB Selective Suspend, and change this to “Disabled”.
Open Processor Power Management > Minimum Processor State> 100%
7. Click OK, then Save Changes
 
HTH.

dwardzala, my system specs are the following:
  Win7 64bit, AMD FX 8120 Eight Core Processor 3.1 GHz, 8GB RAM. 

This is more likely to be caused by some other hardware/drivers than the interface and CPU specs. I use a Focusrite 2nd gen on a far lower spec CPU without those issues (a triple core AMD Phenom 2.3GHz).
 
You could try a tool like latencymon to identify devices that are causing issues (http://www.resplendence.com/latencymon)
 
AMB
 

I am having the same dropout problem with Focusrite Scarlett Solo 2nd Gen. Even if my project is a single audio track and buffer is set to max. (1040) . It gets worse with smaller buffer and/or when I have Midi drums going  The thing is that I have no problems multitracking in Adobe Audition.
 
i have a laptop i5 2.5 dual core with 16G RAM
Windows 10 (64bit)
96k 24 bit config
 
Tried all suggestions above.
- using USB 2 port
- Every thing in the startup tab is disabled except the fingerprint reader
- LatencyMon gives me an all green
- Disabled USB Power Management
- Adjusted Power Options
- Windows will not allow me to configure Windows defender because it is disabled and Norton is installed. Turned off Norton off completely (and disconnected from the network. Turned WiFi off.
 
Still getting drop outs.
 

8/31/16 UPDATE: Focusrite tech support pointed me to a newer driver (4.13) that is not on their website yet. This helped a lot for getting smaller projects to record without drop out.

AntManB
This is more likely to be caused by some other hardware/drivers than the interface and CPU specs. I use a Focusrite 2nd gen on a far lower spec CPU without those issues (a triple core AMD Phenom 2.3GHz).
 
You could try a tool like latencymon to identify devices that are causing issues ()
 
AMB
 

Thanks for your input, I appreciate all who have put forth an idea. However, nothing is solving this problem. I tried the latencymon to identify any issues and it prompted the message that I should be able to play real time audio without dropouts. Yet, this is still a mystery to me.

I'm having similar issues with the first gen 2i4