As a fellow Roland Quad Capture user, I can tell you that at least part of the problem lies with the interface or the drivers, themselves. Check the forum, and you'll find countless posts referencing Roland interfaces.
With that said, most of the times when I have trouble with dropouts, ect, it usually has to do with changes recently made by the operating system, either through updates, or other system changes. Here are a few things that I check first, when random dropouts start happening.
1. Power Options - I've gone through and created a customized power profile for my system which gives me the best settings for music production. Frequently I find that the operating system has, for some reason, switched back to Windows 10's, generic "Balanced" power profile, which is not optimal for music production. In Windows 10, click the Start Button, go to "Settings" then "System", then "Power&Sleep". On that screen you can select a power profile for your system, or go to advanced settings and create a custom profile.
2. USB Power Management - Windows loves to turn things on and off, to conserve power, this can affect performance. To avoid this, I make sure to disable "Power Management" on all my USB devices. This especially drives me crazy with my USB Midi Controller. When the system puts it to sleep, I get the dreaded Midi Device Disconnected message in Sonar. To avoid this, got to Device Manager, and find "Universal Serial Bus Controller" in the list. Double click to open it and then double click each device inside, one at a time. Any that have a "Power Management" tab, go to the tab and make sure to remove the check mark from "Allow The Computer To Turn Off This Device". No more losing USB devices while working.
3. This one really drives me crazy. My laptop, as most, has an on board audio card. Using this at the same time as an external audio card, can cause problems. To avoid this, I go into Device Manager, under "Sound Video And Game Controllers, and disable anything related to the on board audio. Also in device manager, go to "System Devices" and Disable anything related to your laptops on board audio. The problem comes when windows does and update. Often, it will turn all of this junk on again, so I check it often. At least after every windows update.
I'm sure I'll think of something else, but these are the main things that I check antime dropouts start happening.