ccable
This is a custom built PC, no integrated graphics just the 1070.

Your Intel Core i7-6700K has onboard Intel® HD Graphics 530. > https://ark.intel.com/pro...M-Cache-up-to-4_20-GHz
 
You Z170-AR motherboard has a HDMI and displayport connections for the integrated graphics.  The Intel graphics should be enabled in the BIOS if no GPU is installed.

I am also running a Samsung 850 EVO SSD, and it is the best thing that ever happened to this PC.  So that is the least likely to be causing performance issues, if it is running correctly.  Have you run Samsung Magician diagnostics yet?  >  https://www.samsung.com/semiconductor/minisite/ssd/product/consumer/magician/
 
 

Nvidia loads a bunch of software that hampers audio. Two things to try specific to those.
1. Reload nvidia drivers as a clean install, and only check graphics drivers and PhysX.
2. Go into device manager and disable nvidia HD audio drivers.

You say network is disabled, but for others reading this, "automatic network discovery" is one of the top latency issues, and should be disabled.

Reinstalled the nvidia junk, disabled the video card and the HD audios then still received the crackles. Ran the samsung tool, drive condition is: Good. and the firmware is: Latest. TRIM is enabled, ACHI is activated, and RAPID mode is off. Looks like I'm gonna do an OS reinstall. Also searched and made sure the network discovery is off. this machine is a desktop with WiFi just so you know.

If WDM mode (YouTube) has problems, the reason should be huge. I mean not related to 1-2ms delays some drivers can have.
As the first, I will try to use it with different USB cable on different port (sure on PC itself, not with some hub).
As the second I will connect it to another PC to check.

Reinstalling the OS will almost surely not resolve the issue.
 
Disable WiFi and see if the audio crackles disappear.
WiFi is notorious for causing high DPC Latency and causing audio glitches when running at small ASIO buffer sizes.
 
If your audio interface is USB-2, try connecting it to a USB-2 port (instead of USB-3).
Many motherboards have additional 3rd-party USB-3 controllers.
Some audio interfaces (especially older models) tend to have problems with 3rd-party USB-3 controllers.
 

Disabled WiFi, already have the interface in a USB-2. Cable is good, I've used it on my laptop for a year. Would removing Realtek (reinstalling) be of any use?

ccable
Disabled WiFi, already have the interface in a USB-2. Cable is good, I've used it on my laptop for a year. Would removing Realtek (reinstalling) be of any use?

Have you checked that Realtek is working fine, without crackling? Recent Realtek also has ASIO drivers, so you can check that with Sonar and low buffer settings. If that works, WiFi and other DPC related things are not the reason.
 
Assuming the problem is with Focusrite only, I would still recommend to try different cable and port. Also check the driver, they have released new version(s) recently but not all reports I have observed in the internet are positive. You can try older.

ccable
Disabled WiFi, already have the interface in a USB-2. Cable is good, I've used it on my laptop for a year. Would removing Realtek (reinstalling) be of any use?

Generally speaking, disabling (onboard) Realtek sound won't have an appreciable effect on DPC Latency.
 
If the Focusrite is sharing a root-hub with another USB device, that could cause problems.
Azslow3's suggestion to try a different USB port is worth a shot.
 
From what I read above, the DPC Latency report doesn't mention a problem with 3rd-party add-on hardware/driver.
If you've disabled everything that can affect DPC Latency... and you've flashed the BIOS up (and down) with the same results, the problem may be the motherboard.  Strip the machine down to the barest of essentials (necessary to run).
If DPC Latency is still high, I'd swap out the motherboard.
 
With super high DPC Latency, it doesn't matter what audio interface, how it's connected, etc...
You'll hear audio glitches... as the ASIO buffers don't get filled in time (due to the process monopolizing the CPU).

I used a Roland 2x2 as a test, still had same problems. Just tested on my brothers pc and it worked fine. Also, my dad suggested, as you did Jim, that the motherboard may be the problem. Was reading about mine (Z170 AR) and how people have this type of problem almost commonly. Would a sound card be a fix to the issue? And if so would it make a difference if it was USB?