today my computer did not see my motu 1248.  I tried reinstalling the drivers, changing the cable, plugging the cable (usb) into a different port, updating the firmware, etc.  no luck
   sometimes motu discovery app would see it.  and a couple times device manger saw it but said the drivers weren't installed.  UGH!!!!!!

are you using the latest MOTU AVB driver?
 
this was a known issue in Sept./Oct 2016 and solved by driver v2.0+71418 | November 1, 2016
 
http://motu.com/avb/index.html
 

I thought I was but I actually wasn't.  Thanks a lot!  It seems to be working now

HighAndDry
I thought I was but I actually wasn't.  Thanks a lot!  It seems to be working now

my pleasure. would you mind marking this thread as [SOLVED] ???

I have similar issues with a Behringer mixer interface. It's a constant hassle reinstalling drivers, rebooting the system, and so on. It's a 70/30 chance it will work at any given time. Behringer's drivers haven't been updated to Windows 10 yet so it's expected.