Using the new MOTU AVB series with lots of I/O here. 2x 1248 plus ADAT interface (plus if needed also the traveling unit UltraLite). Extremely happy with the options (sound, routing, DSP mixes, networking, etc.). I have virtually all my outboard and synths cabled up and ready to go ... it is like a gigantic console over only 3x 1 rack unit.
The AVB networking is brilliant and works like charm. If you can afford it I would recommend it. Units like the 1248 (or the 16A which you may need) are >1500$ a piece and if you need a lot of I/O you might need 2 or 3 of them. But the system is perfectly scalable, meaning you can buy one now and other later. I actually added the UltraLite lately as it has sufficient I/O for my traveling/live synth rack and when back in the studio all it takes is a single LAN cable to have it all hooked to the studio racks.