Patm300e, I appreciate the link. This was done over and over (installing the unsigned drivers attempts). I had to reinstall Windows 12 times over this. The only thing I did not do at the end was to install earlier version of Windows 10, which I regret because I got the disk with early version, but then I gave up. It was 2 weeks fight. I am actually not 100% sure that it is drivers signing issue, because it does not work with "Unsigned" mode using your method. Presonus wants to believe it is drivers signing but they don't care much and did not really try to solve it. I had strangers on Toms Hardware and KVR Audio helping me much more than Presonus who is responsible for the drivers. They were sounding frustrated that I wanted to fix it, did not reply to e-mails with reports of what we have tried and were just not interested. They did not even tell- they will personally let me know if they release updated drivers- just told me to check the news section of their web site. The problem is that the driver gets installed, computer sees the Mixer, it even forced it to update Firmware on the mixer, and installed new firmware, but Audio is not going through. Just dead. Somebody suggested that it may be Bandwidth of motherboard. Contacted Asus, their supervisor was supposed to report it to Engineers and get back with me, but they never did. People just disappear when I report this problem.
I heard several RME recommendations. It must be good. It just looks boring. And expansive. How is it compared to Universal Audio and MOTU? (wondering). Thank you.