I have scored a couple good subs from Goodwill for $20-$30. Two are Yamaha's and one is a JBL. All were originally sold for well over $200 for home stereo systems. I am a huge fan of finding good old stereo gear at Goodwill.
I only turn the sub on briefly and run a mix through it to check for low end artifacts like pops and once I even found someone tapping their foot on a mike stand. Those don't show in my NMS10.
But for 80% of my mixes I only use the NMS10 and 90% of my mixes are near to bang on because I have used them for 20 years now. This has been in at lot of different rooms too. I'm a huge believer in room treatment and most of my rooms have had some degree of proper treatment used. I've used a few BAD rooms and it makes it very hard to work. You end up depending more on headphones in a bad room.
We all know by now that the NMS10 is possible the worlds most boring speaker to listen to music on. NMS10's and the little Auratones work because they are not coloured.
So I think the more coloured your monitors, the harder it is to learn them.
And the worse the room the harder it will be to produce an accurate mix.