Output from Latency Monitor:-
 
CONCLUSION
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Your system seems to be having difficulty handling real-time audio and other tasks. You may experience drop outs, clicks or pops due to buffer underruns. One problem may be related to power management, disable CPU throttling settings in Control Panel and BIOS setup. Check for BIOS updates.
LatencyMon has been analyzing your system for 2:07:21 (h:mm:ss) on all processors.

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SYSTEM INFORMATION
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Computer name: DESKTOP-VQCRM33
OS version: Windows 10 , 10.0, build: 14393 (x64)
Hardware: X556UAK, ASUSTeK COMPUTER INC.
CPU: GenuineIntel Intel(R) Core(TM) i7-7500U CPU @ 2.70GHz
Logical processors: 4
Processor groups: 1
RAM: 8072 MB total

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CPU SPEED
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Reported CPU speed: 2904 MHz
Note: reported execution times may be calculated based on a fixed reported CPU speed. Disable variable speed settings like Intel Speed Step and AMD Cool N Quiet in the BIOS setup for more accurate results.

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MEASURED INTERRUPT TO USER PROCESS LATENCIES
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The interrupt to process latency reflects the measured interval that a usermode process needed to respond to a hardware request from the moment the interrupt service routine started execution. This includes the scheduling and execution of a DPC routine, the signaling of an event and the waking up of a usermode thread from an idle wait state in response to that event.
Highest measured interrupt to process latency (µs): 1165.752272
Average measured interrupt to process latency (µs): 3.495820
Highest measured interrupt to DPC latency (µs): 1105.454740
Average measured interrupt to DPC latency (µs): 0.810277

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REPORTED ISRs
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Interrupt service routines are routines installed by the OS and device drivers that execute in response to a hardware interrupt signal.
Highest ISR routine execution time (µs): 521.829890
Driver with highest ISR routine execution time: Wdf01000.sys - Kernel Mode Driver Framework Runtime, Microsoft Corporation
Highest reported total ISR routine time (%): 0.000601
Driver with highest ISR total time: HDAudBus.sys - High Definition Audio Bus Driver, Microsoft Corporation
Total time spent in ISRs (%) 0.001005
ISR count (execution time <250 µs): 51078
ISR count (execution time 250-500 µs): 0
ISR count (execution time 500-999 µs): 4
ISR count (execution time 1000-1999 µs): 0
ISR count (execution time 2000-3999 µs): 0
ISR count (execution time >=4000 µs): 0

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REPORTED DPCs
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DPC routines are part of the interrupt servicing dispatch mechanism and disable the possibility for a process to utilize the CPU while it is interrupted until the DPC has finished execution.
Highest DPC routine execution time (µs): 672.180785
Driver with highest DPC routine execution time: iaStorA.sys - Intel(R) Rapid Storage Technology driver - x64, Intel Corporation
Highest reported total DPC routine time (%): 0.035147
Driver with highest DPC total execution time: rspLLL64.sys - Resplendence Latency Monitoring and Auxiliary Kernel Library, Resplendence Software Projects Sp.
Total time spent in DPCs (%) 0.102961
DPC count (execution time <250 µs): 27772914
DPC count (execution time 250-500 µs): 0
DPC count (execution time 500-999 µs): 12739
DPC count (execution time 1000-1999 µs): 0
DPC count (execution time 2000-3999 µs): 0
DPC count (execution time >=4000 µs): 0

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REPORTED HARD PAGEFAULTS
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Hard pagefaults are events that get triggered by making use of virtual memory that is not resident in RAM but backed by a memory mapped file on disk. The process of resolving the hard pagefault requires reading in the memory from disk while the process is interrupted and blocked from execution.
NOTE: some processes were hit by hard pagefaults. If these were programs producing audio, they are likely to interrupt the audio stream resulting in dropouts, clicks and pops. Check the Processes tab to see which programs were hit.
Process with highest pagefault count: latmon.exe
Total number of hard pagefaults 274
Hard pagefault count of hardest hit process: 189
Highest hard pagefault resolution time (µs): 160113.330234
Total time spent in hard pagefaults (%): 0.002339
Number of processes hit: 7

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PER CPU DATA
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CPU 0 Interrupt cycle time (s): 56.041795
CPU 0 ISR highest execution time (µs): 521.829890
CPU 0 ISR total execution time (s): 0.307066
CPU 0 ISR count: 51066
CPU 0 DPC highest execution time (µs): 672.180785
CPU 0 DPC total execution time (s): 21.419945
CPU 0 DPC count: 23539002
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CPU 1 Interrupt cycle time (s): 296.077930
CPU 1 ISR highest execution time (µs): 1.262052
CPU 1 ISR total execution time (s): 0.000014
CPU 1 ISR count: 16
CPU 1 DPC highest execution time (µs): 528.688705
CPU 1 DPC total execution time (s): 0.357785
CPU 1 DPC count: 144570
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CPU 2 Interrupt cycle time (s): 43.848973
CPU 2 ISR highest execution time (µs): 0.0
CPU 2 ISR total execution time (s): 0.0
CPU 2 ISR count: 0
CPU 2 DPC highest execution time (µs): 541.422865
CPU 2 DPC total execution time (s): 9.145670
CPU 2 DPC count: 3907024
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CPU 3 Interrupt cycle time (s): 291.409569
CPU 3 ISR highest execution time (µs): 0.0
CPU 3 ISR total execution time (s): 0.0
CPU 3 ISR count: 0
CPU 3 DPC highest execution time (µs): 520.603650
CPU 3 DPC total execution time (s): 0.545627
CPU 3 DPC count: 195057
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This section here:-
 
"Highest ISR routine execution time (µs): 521.829890
Driver with highest ISR routine execution time: Wdf01000.sys - Kernel Mode Driver Framework Runtime, Microsoft Corporation
Highest reported total ISR routine time (%): 0.000601
Driver with highest ISR total time: HDAudBus.sys - High Definition Audio Bus Driver, Microsoft Corporation
Total time spent in ISRs (%) 0.001005"
 
What are "Kernel Mode Driver Framework Runtime" and "High Definition Audio Bus Driver"?
 
I notice they're both Microsoft.
 
Reading between the lines, would it help if I disabled the Realtek onboard audio driver?
 

Hi, I got a new fast i7 laptop with 32GB RAM and have the same UA25-EX interface. I got LatencyMon to give me stability by disabling the Ethernet port in device manager. My WiFi can stay on all the time. No problems here now. I use my UA25-EX at my office and a RME Babyface Pro in my studio... the RME is way better, but the UA25-EX can still handle 50+ tracks with plugins.
Mark.

Hi, I got a new fast i7 laptop with 32GB RAM and have the same UA25-EX interface. I got LatencyMon to give me stability by disabling the Ethernet port in device manager. My WiFi can stay on all the time. No problems here now. I use my UA25-EX at my office and a RME Babyface Pro in my studio... the RME is way better, but the UA25-EX can still handle 50+ tracks with plugins.
Mark.

Oh Yeah, I also disable my onboard Realtek audio card in device manager.
Mark.

Also, under sound in device manager, I disable High Definition Audio Device and Realtek High Definition Audio... as per a tip from Craig Anderton on the forum. Sorry about the multiple posts.
Mark.

Hi Mark,
 
Thanks for the suggestions, I could not find an ethernet device to disable (even though I believe I have a socket for it), but I am now disabling the following:-

• Realtek PCIe GBE Family Controller
• Realtek High Definition Audio
• Realtek High Definition Audio Controller

I've also found a Bluetooth heading with "enumerators" entries in it, but having already disabled the Bluetooth device, I won't touch those for the time being.
 
I'm going to run the Latency Monitor for a while now and see what happens.

Wait until there's a dropout and you see a Toast notification. Click on the notification's Help button, and it will give you a list of things to try. When I reached the section on recommendations for disk cache tweaks, and then made changes as instructed, my dropout problems stopped once and for all.

@SGodfrey
 
It may be that the real problem is somewhat hidden from view behind the Windows related DLL.
 
The good news is now you have a way of testing whether or not your changes have fixed the issue!! :-)
 
So, at this point, you want to test some of those remaining items like the battery charger for your laptop (is it a laptop?).
 
Check whether the your NIC has a power saving setting. Most do. You want to disable this.
Right click My Computer > Computer Management > Device Manager > Network Adapters > Properties > Power Management

Laptops are always tricky, they tend to have limited bios options and you're almost always stuck with whatever power saving features or hardware they put in there. But it seems like the HD Audio Device might be the problem - this could also be the audio chip on a video card (for HDMI out). I'm sure you can get this working well enough but it can sure be frustrating to track down, hang in there!