What I would do is load up task manager / resource manager or download Process Hacker here:
http://processhacker.sourceforge.net/ Run it while you are doing whatever action causes problems. Run the graphs as well as the lists of processes / services etc and look for anything that might have triggered at the same time you start bogging down.
At this point you are just looking for something that is sucking cycles. Do you happen to notice your hdisk light on solid when it happens? I had a similar problem a few years ago, hesitations. I thought it was a bad mouse but it turned out to be a sick hdisk. Ask me how I discovered it :( . Wasn't pleasant...
Another thing I would try just for grins is to change your screen resolution to a lower value. So make everything big. If you have no problems at the lower resolution, it *could* indicate your graphics card/cpu isn't keeping up. I really, really, really doubt that though because a lot of us are using either real cheap graphics cards or simply the on board Intel video chip which seem to work fine. Might be worth a try though. DAW work barely makes even a cheap graphics work at all.
The key is to capture whatever is causing the slow down and unfortunately that is not going to be easy unless you get lucky and see xxyyzz.exe kicking off every time you get slowdowns.
Just some things to investigate.