I'd recommend anything RME.  I have a UFX and the drivers have always been solid.

I haven't had any problems with Presonus. I'm using their Fire studio Tube. The darned thing won't break so I can get something else. :) I probably won't replace it until it dies.

Another vote for RME. I have an UCX and use it on a USB 3 port. It's using the USB 2 standard but is fully compatible with USB 3. It also has firewire. My lowest RTL is around 3ms, but usually there is no reason to go that low as the TotalMix software has the most flexible direct monitoring options on the market.

They're pricey though, I got mine second hand.

Yet another recommendation for RME. I use the RME UFX. I know RME was not in your original post, but simply put, the RME products are the top of class when it comes to audio interfaces. It is the measuring rod by which all others are judged. An argument could be made about Lynx or Apogee, but even they are measured by the standards of RME. 

For what its worth, I have read about some issues with the Presonus 192 and using usb3.
 
I too will soon be in the market for a new interface, and I have been looking at RME and MOTU...  I will probably go with the RME as I read some reviews regarding the MOTU drivers and Win 10.  The MOTU seems to be fairly reliable with the OSX.   I take the reviews with a large grain of salt though, as there will always be unhappy customers, and they seem to post more than others.  Will be interested to see what you end up with!
Salud,
Freq

bokchoyboy
 
I too will soon be in the market for a new interface, and I have been looking at RME and MOTU...  I will probably go with the RME as I read some reviews regarding the MOTU drivers and Win 10. 

The latest MOTU generation interfaces (AVB) and win10 have a relative short history as it looks like MOTU focussed first on Mac drivers and only afterwards ironed-out the windows drivers.  Being one of the people who had issues with MOTU in the last fall, I need to comment here that a lot has happened in the past few months and MOTU now provides excellent drivers (they were always rock solid, but had some device connection issues and crackling problems under certain conditions, which are now solved).  Support from MOTU was excellent BTW.
 
RME has a track record of superb performance, so IMHO it is down to personal preference which one to chose, but I would look no further in terms of brands (anyone remember the support from e.g. Roland? Of course not, it does not exist!). I'd go with either RME or MOTU, as both companies also provide a cost-effective interfaces (RME Babyface, MOTU Ultralite). I needed a lot of IO and while you can also chain several RMEs, MOTU AVB here seems to be the winner when it comes to scalability and networked solutions.

We're you referring to the MOTU 624? I was interested in that since my 192 is not suiting my needs.

highlandermak
We're you referring to the MOTU 624? I was interested in that since my 192 is not suiting my needs.

Yes. Anything with from the AVB series as they all use the same driver. I'm actually using 2x 1248 which is the big brother of the 624 and an UltraLite when I travel. Very nice units, superb low noise floor, totally quiet ... just connect them with a standard LAN cable and units talk to each other across rooms ... routing options are intiimmidating at first, though, so plan on learning how to work all these options before sending the unit(s) back ;-)

Awesome thanks. I heard for the PC there were serious problems with the unit and was concerned if it was hardware or software related. I was hoping software which is what it is sounding like if its been resolved :)

+1 for RME.
Babyface Pro owner and happy as a shig in pit.......