Disable the 64bit Double Precision Engine in Preference > Audio > Driver Settings (if it is enabled)

bitflipper
 This is a most peculiar set of symptoms. The pop is almost certainly being generated within the plugin.

After messing around with it a little more, I'm pretty sure you're right. 

I made a video of it:  https://www.youtube.com/watch?v=9xWVsoES8vg

I don't hear it when I turn the channel volume down.  The pop doesn't always register on SONAR's meters, which is why I was confused earlier.  When I recorded the video I noticed the meters jumping.  Why would there be so much noise from just switching a preset?  

This isn't the exact same sound that it's made before, but it's pretty close.  It's usually more of an explosive POP! sound.  I'm noticing that it happens the most with Matrix-12 presets, but I can't say for certain if that's the only one.

a lot of info here to process but I prefer the old fashion way, problem solve it.
Un plug everything and use headphones to prevent damage to your speakers. this way youll only lose some hearing . Anyway, try some other plug ins and compare. also try some of the suggestions by others here. it could also be some sort of interference. or possibly a hardware (mouse or keyboard) or a battery dying in a mouse or keyboard.
 
I had a wireless connection once that only screwed with me when I clicked on one kind of plug in. (im not sure if its related) but in my case, im guessing it was the plug in was checking for an update upon each time being loaded.
 
Are you using the dongle ? that could be a part of it right there.
 

Thanks everyone, I've got a much better idea of what's happening now.

When working in Analog Lab, switching to almost any Matrix-12 patch from any of the other synths causes the popping/explosion sound - some sort of quirk with Arturia's analog emulation I'm guessing.  It's avoidable by not using Analog Lab and just using each synth directly, although I'd rather have everything in one window.

I posted about it (again) on the Arturia forums, but I'm doubtful anyone over there will respond.  (Not trying to badmouth Arturia, but the forum community here is much better.)

I would suggest that you put this excellent, free auto-mute plug-in at the very end of you signal chain on your master bus: 
Ice9 by Cerebus Audio (sorry I am unable to post a link as this is my first post on this forum).
 
Google 'Cerberus Audio Ice9'.
 
You should use it even after you have found the root cause of your issue. It could save your both speakers and your hearing.
I personally would most definitely not try to save my speakers by using headphones.
You can replace damaged speakers. Your ears are the most important piece of equipment that you own.
They are irreplaceable.

Looking at your video this really looks like a bug in the plugin when its loading a preset.
SONAR isn't typically aware of the preset change in the plugin. However it is streaming audio through the plugin. If the plugin doesn't properly handle streaming while a preset is loaded it could cause problems. It could also be a multiprocessing issue in the plugin.
I'll forward this thread to Arturia as well.

jackroller
Thanks everyone, I've got a much better idea of what's happening now.

When working in Analog Lab, switching to almost any Matrix-12 patch from any of the other synths causes the popping/explosion sound - some sort of quirk with Arturia's analog emulation I'm guessing.  It's avoidable by not using Analog Lab and just using each synth directly, although I'd rather have everything in one window.

I posted about it (again) on the Arturia forums, but I'm doubtful anyone over there will respond.  (Not trying to badmouth Arturia, but the forum community here is much better.)

Analog Lab!  Aha!!!!!  Makes sense.  AL has been weird for me too...BTW great screen shots.  I use AL when I want to use presets that combine for me multiple Arturia synths.  Since you were using it for only one synth in each of the 4 instances, you had an easy recovery by just swapping out AL for the SEM. Prophet, etc.
 
This thread is amazing.  I thought this problem was a real head scratcher, but it was diagnosed and solved.
Analog Lab!  I have all those plugs and will see if I can duplicate.

jackroller

After messing around with it a little more, I'm pretty sure you're right. 

I made a video of it:  https://www.youtube.com/watch?v=9xWVsoES8vg

I don't hear it when I turn the channel volume down.  The pop doesn't always register on SONAR's meters, which is why I was confused earlier.  When I recorded the video I noticed the meters jumping.  Why would there be so much noise from just switching a preset?  

This isn't the exact same sound that it's made before, but it's pretty close.  It's usually more of an explosive POP! sound.  I'm noticing that it happens the most with Matrix-12 presets, but I can't say for certain if that's the only one.

That sound...does it sound like a convolution reverb "background" to you?  Then there is the popping...does the tempo of the popping match your project tempo, or perhaps the tempo somewhere in the settings for that preset?  Since Analog Lab is forcing all it's presets to be routed to "omni", could the preset change involving the Matrix 12 to one of your other tracks, be triggering a reverb or delay artifact?  Just guessing here.  Great video.  Really helpful.  Goin' in now to investigate...
 
I have Analog Lab 2 ver. 2.0.2.98...don't know yet if that's up to date.  Will check.
Added:  Notice your meter, on the 4th AL instance track, jumps a full second after the sound is heard...
Added:  You are using "simple instrument" tracks.  Try "split instrument track" on track 10 and see if you get  readings on both the audio and midi meters when you change the preset.
 
Result:  Duplicated your settings and tracks exactly and works fine.  The only difference is you used the floating window for viewing Analog Lab 2 and I put each one including Spark in the Multidock after setting them up.  Used simple instrument tracks too.

NM

Thedoccal
 
Added:  You are using "simple instrument" tracks.  Try "split instrument track" on track 10 and see if you get  readings on both the audio and midi meters when you change the preset.
 
Result:  Duplicated your settings and tracks exactly and works fine.  The only difference is you used the floating window for viewing Analog Lab 2 and I put each one including Spark in the Multidock after setting them up.  Used simple instrument tracks too.

My tracks are split, I just have the MIDI tracks hidden in the Console View.   I double checked and there is no reading on the MIDI track meters when it happens.